San Francisco 49ers vs. Buffalo Bills: Head To Head Stats<\/h2>\n
The 49ers and Bills have played each other 13 times, and it\u2019s been a pretty close rivalry. The Bills are just ahead, winning 7 of those games to the Niners\u2019 6. It\u2019s not one of the most talked-about rivalries, but every time they play, there are some fun moments.<\/p>\n
Lately, the Bills have had the edge. They beat the 49ers 34-24 in 2020, and before that, they smoked them 45-16 back in 2016. The Bills even had a 41-7 win in 2004. But don\u2019t sleep on the 49ers\u2014they\u2019ve had some big wins, too, like when they crushed Buffalo 45-3 in 2012 or shut them out 35-0 in 2001. It\u2019s been a pretty even mix of wins and losses between them.<\/p>\n
There\u2019ve also been some close, down-to-the-wire games, like in 1992 when the Bills barely got by with a 34-31 win. The Niners won 27-17 in 1995, and they also won 23-10 in 1983. It\u2019s a rivalry that\u2019s been around for a while, and even if the games aren\u2019t always high-profile, you know it\u2019s going to be competitive every time these two face off.<\/p>\n
San Francisco 49ers vs. Buffalo Bills: Probable Starting Lineup<\/h2>\n
Here\u2019s a look at the 49ers\u2019 starting lineup: At quarterback, it\u2019s\u00a0Brandon Allen<\/a>. Running back is Christian McCaffrey, with\u00a0Deebo Samuel<\/a> and Jauan Jennings as the starting wide receivers. George Kittle is locked in at tight end, and Jaylen Moore takes the spot at offensive tackle.<\/p>\n For the Bills, Josh Allen leads the offense as quarterback, while James Cook is the starting running back. Amari Cooper<\/a>\u00a0and\u00a0<\/span>Khalil Shakir<\/a>\u00a0are the wide receivers, and Dawson Knox holds down the tight end. Dion Dawkins is the offensive tackle on their line.<\/span><\/p>\n For the Bills, a bunch of guys are dealing with injuries, but most are still practicing. Tight end Quintin Morris has a shoulder issue, and defensive end Casey Toohill has a knee problem, but they\u2019re both good to go in practice. The same goes for linebacker Dorian Williams, who\u2019s also dealing with a knee injury but is still participating. A few other guys like Spencer Brown (ankle) and Reggie Gilliam (hip) are all good to go, too. Keon Coleman, the wide receiver, has a wrist issue but is only limited in practice. Some other big names like Amari Cooper (wrist) and Curtis Samuel (pectoral) are practicing fine, though. On the other hand, Dalton Kincaid (knee) hasn\u2019t been participating, which is something to keep an eye on.<\/p>\n![\"San](\"https:\/\/www.totalprosports.com\/wp-content\/uploads\/2024\/11\/San-Francisco-49ers-vs.-Buffalo-Bills-2-1024x683.jpg\")
San Francisco 49ers vs. Buffalo Bills: Injuries Update<\/h2>\n